Alcohol use disorders may lead to progression of HCC in diabetic patients

Source/Disclosures

Source:

Parlati L, et al. Abstract OS047. Presented at: International Liver Congress; June 22-26, 2022; London (hybrid meeting).

Disclosures:
Healio was unable to confirm relevant financial information at the time of publication.


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LONDON — Alcohol abuse was the primary trigger for liver disease progression to hepatocellular carcinoma in a subset of French patients with type 2 diabetes, according to data presented at the International Liver Congress.

“History of alcohol use disorders accounted for more than half of the burden of HCC in patients with type 2 diabetes in France from 2011 to 2020”, Lucy Parlati, said a doctoral student at the Cochin Institute in Paris. “Male patients with type 2 diabetes, aged 65 to 70, with a history of alcohol use disorders had a higher risk of HCC.”

couple drinking alcohol

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In a longitudinal retrospective study, Parlati and colleagues analyzed 2,883,684 patients (mean age, 67 years; 54% male) with type 2 diabetes using the National Hospital Discharge Database from 2011 to 2020. Researchers measured HCC incidence, liver disease progression, and mortality.

According to the results, the incidence of HCC was 1.19 (95% CI, 1.17-1.21) per 1000 person-years at risk, which totaled 26,136 cases (0.9%) over 12,504,690 patient-years. The researchers further recorded a history of alcohol use disorders in 55% of the patients and liver-related non-metabolic risk factors in 21% of the patients.

In patients without well-identified risk factors for liver disease progression, HCC

the incidence was 0.57 (95% CI, 0.55-0.58) per 1000 person-years at risk. A higher risk of HCC was independently associated with male sex, age 40-70, alcohol use disorder (adjusted OR = 20.8; 95% CI, 20-21.5 ) and obesity (aOR = 1.24; 95% CI, 1.2-1.28) .

“Alcohol consumption is a modifiable risk factor and patients with type 2 diabetes should be advised to abstain from alcohol,” Parlati said.


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